MolNFT v1 · #145741 · protein
Structure of ATTPC1 D376A
6CX0 · Two pore calcium channel protein 1: “Structure of ATTPC1 D376A”. X-ray diffraction, 2 ligands (FJ7, CA), 10 pockets (best druggability 0.74). MolNFT v1 #145741 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6CX0
- Type
- protein
- Length
- 619 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Two pore calcium channel protein 1
- UniProt
- Q94KI8
- Ligands
- FJ7, CA
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Two pore calcium channel protein 1 | protein | 619 | 74% helix, 0% strand | Q94KI8 |
Ligands and binding sites
- FJ7 · (1S,3R)-1-(3-{[4-(2-fluorophenyl)piperazin-1-yl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid · ligand · chains A
- CA · Calcium ion · metal · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1101 | 0.74 | 0.76 | 82 | empty |
| 2 | 81 | 0.63 | 0.91 | 23 | empty |
| 3 | 220 | 0.56 | 0.79 | 24 | empty |
| 4 | 81 | 0.54 | 0.86 | 19 | empty |
| 5 | 225 | 0.53 | 0.76 | 26 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94KI8
- Elsewhere: RCSB PDB 6CX0 · PDBe 6CX0 · UniProt Q94KI8
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