MolNFT v1 · #145121 · protein
Human pyruvate dehydrogenase complex E1 component V138M mutation
6CER: “Human pyruvate dehydrogenase complex E1 component V138M mutation”. X-ray diffraction, 2 ligands (TPP, MG). MolNFT v1 #145121 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6CER
- Type
- protein
- Length
- 2,661 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P08559, P11177
- Ligands
- TPP, MG
Structure
x-ray diffraction · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 342 | — | P08559 |
| B, F | — | protein | 330 | — | P11177 |
| C | — | protein | 328 | — | P08559 |
| D, H | — | protein | 331 | — | P11177 |
| E | — | protein | 340 | — | P08559 |
| G | — | protein | 329 | — | P08559 |
Ligands and binding sites
- TPP · Thiamine diphosphate · ligand · 4 copies · chains A, D, B, C, E, H, F, G
- MG · Magnesium ion · metal · 2 copies · chains E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6CER · Human pyruvate dehydrogenase complex E1 component V138M mutation · the same entry in another collection · chain H against H, TM-score 1.00
- P11177 · AlphaFold monomer V2.0 prediction for pyruvate dehydrogenase E1 component subunit beta… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P08559 · AlphaFold monomer V2.0 prediction for pyruvate dehydrogenase E1 component subunit alpha… · a predicted model of the same protein · chain C against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08559
- Every structure of UniProt P11177
- Elsewhere: RCSB PDB 6CER · PDBe 6CER · UniProt P08559 · UniProt P11177
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