UniProt P11177
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (P11177)
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (UniProt P11177), EC 1.2.4.1: 18 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 23 pockets. Binding sites, druggability and experiment…
- UniProt
- P11177
- Protein
- Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- EC
- 1.2.4.1
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 23 · 2 records with a druggable one
Structures
19 records of P11177 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1NI4 | Human pyruvate dehydrogenase | x-ray diffraction | B, D | — | — |
| 1NI4 | Human pyruvate dehydrogenase | x-ray diffraction | B, D | — | — |
| 2OZL | Human pyruvate dehydrogenase S264E variant | x-ray diffraction | B, D | — | — |
| 2OZL | Human pyruvate dehydrogenase S264E variant | x-ray diffraction | B, D | — | — |
| 3EXE | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase… | x-ray diffraction | B, D, F, H | — | — |
| 3EXE | Crystal structure of the pyruvate dehydrogenase (E1P) component of human pyruvate dehydrogenase… | x-ray diffraction | B, D, F, H | — | — |
| 3EXF | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase… | x-ray diffraction | B, D, F, H | — | — |
| 3EXF | Crystal structure of the pyruvate dehydrogenase (E1P) component of human pyruvate dehydrogenase… | x-ray diffraction | B, D, F, H | — | — |
| 3EXG | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase… | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X, Z, 2, 4, 6 | — | — |
| 3EXG | Crystal structure of the pyruvate dehydrogenase (E1P) component of human pyruvate dehydrogenase… | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X, Z, 2, 4, 6 | — | — |
| 3EXH | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase… | x-ray diffraction | B, D, F, H | — | — |
| 3EXH | Crystal structure of the pyruvate dehydrogenase (E1P) component of human pyruvate dehydrogenase… | x-ray diffraction | B, D, F, H | — | — |
| 3EXI | Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase… | x-ray diffraction | B | — | — |
| 3EXI | Crystal structure of the pyruvate dehydrogenase (E1P) component of human pyruvate dehydrogenase… | x-ray diffraction | B | — | — |
| 6CER | Human pyruvate dehydrogenase complex E1 component V138M mutation | x-ray diffraction | B, D, F, H | TPP | 14 (best 0.77) |
| 6CER | Human pyruvate dehydrogenase complex E1 component V138M mutation | x-ray diffraction | B, D, F, H | TPP | — |
| 6CFO | Human pyruvate dehydrogenase E1 component complex with covalent tdp adduct acetyl phosphinate | x-ray diffraction | B, D | A5X | 9 (best 0.80) |
| 6CFO | Human pyruvate dehydrogenase E1 component complex with covalent tdp adduct acetyl phosphinate | x-ray diffraction | B, D | A5X | — |
| P11177 | AlphaFold monomer V2.0 prediction for pyruvate dehydrogenase E1 component subunit beta… | predicted | A | — | — |
Ligands
Experiment against prediction
- 3EXE chain B against the predicted model P11177: TM-score 1.00, RMSD 0.17 Å
- 3EXE chain B against the predicted model P11177: TM-score 1.00, RMSD 0.17 Å
- 3EXH chain B against the predicted model P11177: TM-score 1.00, RMSD 0.20 Å
- 3EXH chain B against the predicted model P11177: TM-score 1.00, RMSD 0.20 Å
- 2OZL chain B against the predicted model P11177: TM-score 1.00, RMSD 0.23 Å
- 2OZL chain B against the predicted model P11177: TM-score 1.00, RMSD 0.23 Å
- 1NI4 chain B against the predicted model P11177: TM-score 1.00, RMSD 0.24 Å
- 1NI4 chain B against the predicted model P11177: TM-score 1.00, RMSD 0.24 Å
- 6CER chain F against the predicted model P11177: TM-score 1.00, RMSD 0.26 Å
- 6CFO chain B against the predicted model P11177: TM-score 1.00, RMSD 0.25 Å
Elsewhere
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