MolNFT v1 · #144565 · protein
Structure of a single-chain BETA3 integrin
6BXJ · Chimera protein of integrin beta-3 and integrin alpha-L: “Structure of a single-chain BETA3 integrin”. X-ray diffraction, 2 ligands (NAG, MG), 6 pockets (best druggability 0.72). MolNFT v1 #144565 on GenesisL1: 3D structure, binding…
- PDB
- 6BXJ
- Type
- protein
- Length
- 619 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chimera protein of integrin beta-3 and integrin alpha-L
- UniProt
- P05106, P20701
- Ligands
- NAG, MG
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chimera protein of integrin beta-3 and integrin alpha-L | protein | 619 | 20% helix, 31% strand | P05106, P20701 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 884 | 0.72 | 0.76 | 73 | empty |
| 2 | 673 | 0.65 | 0.74 | 58 | empty |
| 3 | 191 | 0.57 | 0.81 | 30 | empty |
| 4 | 86 | 0.46 | 0.81 | 23 | empty |
| 5 | 75 | 0.33 | 0.75 | 19 | empty |
Modifications
Observed in the structure: 26 disulfide, 4 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05106
- Every structure of UniProt P20701
- Elsewhere: RCSB PDB 6BXJ · PDBe 6BXJ · UniProt P05106 · UniProt P20701
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