MolNFT v1 · #144481 · protein
Crystal structure of porcine aminopeptidase-N with aspartic acid
6BV1 · Aminopeptidase N: “Crystal structure of porcine aminopeptidase-N with aspartic acid”. X-ray diffraction, 4 ligands (ASP, NAG, ZN), 7 pockets (best druggability 0.64). MolNFT v1 #144481 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6BV1
- Type
- protein
- Length
- 902 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Aminopeptidase N
- EC
- 3.4.11.2
- UniProt
- P15145
- Ligands
- ASP, NAG, ZN, SO4
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Aminopeptidase N (EC 3.4.11.2) | protein | 902 | 44% helix, 20% strand | P15145 |
Ligands and binding sites
- ASP · Aspartic acid · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 23 copies · chains A
- ZN · Zinc ion · metal · chains A
- SO4 · Sulfate ion · ion · 10 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 576 | 0.64 | 0.76 | 37 | empty |
| 2 | 390 | 0.64 | 0.79 | 49 | empty |
| 3 | 471 | 0.62 | 0.76 | 41 | empty |
| 4 | 471 | 0.58 | 0.74 | 54 | ASP, SO4 |
| 5 | 118 | 0.38 | 0.74 | 18 | empty |
Modifications
Observed in the structure: 11 glycan, 2 disulfide (N-glycosylation, disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15145
- Elsewhere: RCSB PDB 6BV1 · PDBe 6BV1 · UniProt P15145
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