MolNFT v1 · #144422 · protein

Human MGLU8 receptor complexed with glutamate

6BSZ · Metabotropic glutamate receptor 8: “Human MGLU8 receptor complexed with glutamate”. X-ray diffraction, 3 ligands (GGL, NAG, SO4), 8 pockets (best druggability 0.82). MolNFT v1 #144422 on GenesisL1: 3D structure, binding sites and…

PDB: 6BSZ
Type: protein
Length: 878 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metabotropic glutamate receptor 8
UniProt: O00222
Ligands: GGL, NAG, SO4
Pockets: 8 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Metabotropic glutamate receptor 8	protein	445	35% helix, 20% strand	O00222
B	Metabotropic glutamate receptor 8	protein	433	35% helix, 21% strand	O00222

Ligands and binding sites

GGL · Gamma-L-glutamic acid · ligand · 2 copies · chains A, B
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	922	0.82	0.84	91	GGL, SO4
2	589	0.77	0.83	87	GGL
3	91	0.57	0.86	15	empty
4	128	0.57	0.83	29	empty
5	94	0.56	0.85	16	empty

Interfaces

1 interface between chains.

A–B · 799 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide, 2 glycan (disulfide, N-glycosylation).

Compared structures

6BSZ · Human mGlu8 Receptor complexed with glutamate · the same entry in another collection · chain A against A, TM-score 1.00
O00222 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 8 (O00222) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00222
Elsewhere: RCSB PDB 6BSZ · PDBe 6BSZ · UniProt O00222

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.