UniProt O00222
Metabotropic glutamate receptor 8 (O00222)
Metabotropic glutamate receptor 8 (UniProt O00222): 5 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O00222
- Protein
- Metabotropic glutamate receptor 8
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 8 · 1 record with a druggable one
Structures
6 records of O00222 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BSZ | Human mGlu8 Receptor complexed with glutamate | x-ray diffraction | A, B | GLU, NAG, SO4 | 8 (best 0.82) |
| 6BSZ | Human MGLU8 receptor complexed with glutamate | x-ray diffraction | A, B | NAG, SO4 | — |
| 6BT5 | Human mGlu8 Receptor complexed with L-AP4 | x-ray diffraction | A, B | NAG | — |
| 6BT5 | Human MGLU8 receptor complexed with L-AP4 | x-ray diffraction | A, B | E7P, NAG | — |
| 6E5V | Human MGLU8 receptor amino terminal domain in complex with (S)-3,4- dicarboxyphenylglycine (dcpg) | x-ray diffraction | A, B | HVG, CL | — |
| O00222 | AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 8 (O00222) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6E5V chain A against the predicted model O00222: TM-score 0.99, RMSD 0.75 Å
- 6E5V chain B against the predicted model O00222: TM-score 0.98, RMSD 1.32 Å
- 6BSZ chain B against the predicted model O00222: TM-score 0.95, RMSD 1.68 Å
- 6BT5 chain B against the predicted model O00222: TM-score 0.95, RMSD 1.69 Å
- 6BSZ chain B against the predicted model O00222: TM-score 0.95, RMSD 1.68 Å
- 6BT5 chain B against the predicted model O00222: TM-score 0.95, RMSD 1.69 Å
- 6BT5 chain A against the predicted model O00222: TM-score 0.94, RMSD 2.04 Å
- 6BT5 chain A against the predicted model O00222: TM-score 0.94, RMSD 2.04 Å
- 6BSZ chain A against the predicted model O00222: TM-score 0.94, RMSD 1.95 Å
- 6BSZ chain A against the predicted model O00222: TM-score 0.94, RMSD 1.95 Å
Elsewhere
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