MolNFT v1 · #144006 · protein
Solution NMR structure of BRD3 et domain bound to BRG1 peptide
6BGH · Bromodomain-containing protein 3: “Solution NMR structure of BRD3 et domain bound to BRG1 peptide”. Solution nmr, 1 pocket (best druggability 0.35). MolNFT v1 #144006 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6BGH
- Type
- protein
- Length
- 99 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain-containing protein 3; BRD3_ET
- UniProt
- Q15059
- Pockets
- 1 · best druggability 0.35
Structure
solution nmr · 2 distinct chains · 44% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bromodomain-containing protein 3 | protein | 87 | 51% helix, 0% strand | Q15059 |
| B | BRD3_ET | protein | 12 | 0% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 85 | 0.35 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 735 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6BGH · Solution NMR structure of Brd3 ET domain bound to Brg1 peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q15059 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) · a predicted model of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15059
- Elsewhere: RCSB PDB 6BGH · PDBe 6BGH · UniProt Q15059
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