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Solution NMR structure of BRD3 et domain bound to BRG1 peptide

Analyse Solution NMR structure of BRD3 et domain bound to BRG1 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6BGH
Type: protein
Length: 99 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bromodomain-containing protein 3; BRD3_ET
UniProt: Q15059
Pockets: 1 · best druggability 0.35

Structure

solution nmr · 2 distinct chains · 44% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bromodomain-containing protein 3	protein	87	51% helix, 0% strand	Q15059
B	BRD3_ET	protein	12	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	85	0.35	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 735 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

6BGH · Solution NMR structure of Brd3 ET domain bound to Brg1 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q15059 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 3 (Q15059) · a predicted model of the same protein · chain A against A, TM-score 0.62

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15059
Elsewhere: RCSB PDB 6BGH · PDBe 6BGH · UniProt Q15059

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