MolNFT v1 · #14388 · protein

Crystal structure of unactivated apo insulin-like growth factor-1 receptor kinase domain

1M7N · Insulin-like growth factor I receptor: “Crystal structure of unactivated apo insulin-like growth factor-1 receptor kinase domain”. X-ray diffraction, 8 pockets (best druggability 0.68). MolNFT v1 #14388 on GenesisL1: 3D structure…

PDB: 1M7N
Type: protein
Length: 598 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Insulin-like growth factor I receptor
EC: 2.7.1.112
UniProt: P08069
Pockets: 8 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Insulin-like growth factor I receptor (EC 2.7.1.112)	protein	299	38% helix, 15% strand	P08069

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	424	0.68	0.80	51	empty
2	292	0.62	0.79	31	empty
3	145	0.53	0.80	29	empty
4	104	0.40	0.76	19	empty
5	91	0.39	0.77	19	empty

Interfaces

1 interface between chains.

A–B · 736 Å² buried · 25 hydrogen bonds · protein-protein

Compared structures

1M7N · Crystal Structure of Unactivated APO Insulin-like Growth Factor-1 Receptor Kinase Domain · the same entry in another collection · chain A against A, TM-score 1.00
P08069 · AlphaFold monomer V2.0 prediction for insulin-like growth factor 1 receptor (P08069) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08069
Elsewhere: RCSB PDB 1M7N · PDBe 1M7N · UniProt P08069

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