Research workbench
Crystal structure of unactivated apo insulin-like growth factor-1 receptor kinase domain
Analyse Crystal structure of unactivated apo insulin-like growth factor-1 receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1M7N
- Type
- protein
- Length
- 598 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor I receptor
- EC
- 2.7.1.112
- UniProt
- P08069
- Pockets
- 8 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Insulin-like growth factor I receptor (EC 2.7.1.112) | protein | 299 | 38% helix, 15% strand | P08069 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 424 | 0.68 | 0.80 | 51 | empty |
| 2 | 292 | 0.62 | 0.79 | 31 | empty |
| 3 | 145 | 0.53 | 0.80 | 29 | empty |
| 4 | 104 | 0.40 | 0.76 | 19 | empty |
| 5 | 91 | 0.39 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 736 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 1M7N · Crystal Structure of Unactivated APO Insulin-like Growth Factor-1 Receptor Kinase Domain · the same entry in another collection · chain A against A, TM-score 1.00
- P08069 · AlphaFold monomer V2.0 prediction for insulin-like growth factor 1 receptor (P08069) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08069
- Elsewhere: RCSB PDB 1M7N · PDBe 1M7N · UniProt P08069
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