MolNFT v1 · #143860 · protein
A complex between pH domain of P190RHOGEF and activated rhoa bound to a GTP analog
6BC0 · Rho guanine nucleotide exchange factor 28: “A complex between pH domain of P190RHOGEF and activated rhoa bound to a GTP analog”. X-ray diffraction, 2 ligands (GSP, MG), 3 pockets (best druggability 0.59). MolNFT v1 #143860 on…
- PDB
- 6BC0
- Type
- protein
- Length
- 310 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho guanine nucleotide exchange factor 28; Transforming protein rhoa
- UniProt
- Q8N1W1, P61586
- Ligands
- GSP, MG
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rho guanine nucleotide exchange factor 28 | protein | 131 | 21% helix, 42% strand | Q8N1W1 |
| F | Transforming protein rhoa | protein | 179 | 40% helix, 26% strand | P61586 |
Ligands and binding sites
- GSP · 5'-guanosine-diphosphate-monothiophosphate · ligand · chains F
- MG · Magnesium ion · metal · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 248 | 0.59 | 0.79 | 32 | empty |
| 2 | 163 | 0.53 | 0.79 | 32 | MG, GSP |
| 3 | 62 | 0.40 | 0.80 | 15 | empty |
Interfaces
1 interface between chains.
- A–F · 645 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6BC0 · A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog · the same entry in another collection · chain A against A, TM-score 1.00
- P61586 · AlphaFold monomer V2.0 prediction for transforming protein rhoa (P61586) · a predicted model of the same protein · chain F against A, TM-score 0.99
- Q8N1W1 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 28 (Q8N1W1) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8N1W1
- Every structure of UniProt P61586
- Elsewhere: RCSB PDB 6BC0 · PDBe 6BC0 · UniProt Q8N1W1 · UniProt P61586
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