UniProt Q8N1W1
Rho guanine nucleotide exchange factor 28 (Q8N1W1)
Rho guanine nucleotide exchange factor 28 (UniProt Q8N1W1): 4 experimental structures and 1 predicted model on GenesisL1, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8N1W1
- Protein
- Rho guanine nucleotide exchange factor 28
- Experimental structures
- 4
- Predicted models
- 1
- Pockets
- 32 · 5 records with a druggable one
Structures
5 records of Q8N1W1 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BC0 | A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog | x-ray diffraction | A | — | 2 (best 0.59) |
| 6BC0 | A complex between pH domain of P190RHOGEF and activated rhoa bound to a GTP analog | x-ray diffraction | A | — | 2 (best 0.59) |
| 6BC1 | A Complex between PH Domain of p190RhoGEF and Activated Rac1 Bound to a GTP Analog | x-ray diffraction | C, D | — | 6 (best 0.65) |
| 6BC1 | A complex between pH domain of P190RHOGEF and activated RAC1 bound to a GTP analog | x-ray diffraction | C, D | — | 6 (best 0.65) |
| Q8N1W1 | AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 28 (Q8N1W1) | predicted | A | — | 16 (best 0.74) |
Experiment against prediction
- 6BC1 chain C against the predicted model Q8N1W1: TM-score 0.98, RMSD 0.71 Å
- 6BC1 chain C against the predicted model Q8N1W1: TM-score 0.98, RMSD 0.71 Å
- 6BC1 chain D against the predicted model Q8N1W1: TM-score 0.97, RMSD 0.75 Å
- 6BC1 chain D against the predicted model Q8N1W1: TM-score 0.97, RMSD 0.75 Å
- 6BC0 chain A against the predicted model Q8N1W1: TM-score 0.96, RMSD 0.89 Å
- 6BC0 chain A against the predicted model Q8N1W1: TM-score 0.96, RMSD 0.89 Å
Elsewhere
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