MolNFT v1 · #143851 · protein
Model for extended volume of truncated monomeric cytohesin-3 (GRP1; amino acids 63-399) E161A ARF6 Q67L fusion protein
6BBQ · Cytohesin-3,ADP-ribosylation factor 6: “Model for extended volume of truncated monomeric cytohesin-3 (GRP1; amino acids 63-399) E161A ARF6 Q67L…”. Electron microscopy, 3 ligands (GTP, 4IP, MG), 8 pockets (best druggability 0.67).…
- PDB
- 6BBQ
- Type
- protein
- Length
- 520 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytohesin-3,ADP-ribosylation factor 6
- UniProt
- O08967, P62330
- Ligands
- GTP, 4IP, MG
- Pockets
- 8 · best druggability 0.67
Structure
electron microscopy · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytohesin-3,ADP-ribosylation factor 6 | protein | 520 | 41% helix, 18% strand | O08967, P62330 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A
- 4IP · Inositol-(1,3,4,5)-tetrakisphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 443 | 0.67 | 0.79 | 42 | empty |
| 2 | 155 | 0.46 | 0.76 | 24 | empty |
| 3 | 110 | 0.45 | 0.79 | 28 | GTP, MG |
| 4 | 136 | 0.45 | 0.76 | 23 | empty |
| 5 | 54 | 0.39 | 0.81 | 13 | empty |
Compared structures
- 6BBQ · Model for extended volume of truncated monomeric Cytohesin-3 (Grp1; amino acids 63-399)… · the same entry in another collection · chain A against A, TM-score 1.00
- O08967 · AlphaFold monomer V2.0 prediction for cytohesin-3 (O08967) · a predicted model of the same protein · chain A against A, TM-score 0.37
- P62330 · AlphaFold monomer V2.0 prediction for ADP-ribosylation factor 6 (P62330) · a predicted model of the same protein · chain A against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O08967
- Every structure of UniProt P62330
- Elsewhere: RCSB PDB 6BBQ · PDBe 6BBQ · UniProt O08967 · UniProt P62330
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