MolNFT v1 · #143802 · protein
The structure of human camkii with bound inhibitor
6BAB: “The structure of human camkii with bound inhibitor”. X-ray diffraction, 1 ligand (D0S). MolNFT v1 #143802 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6BAB
- Type
- protein
- Length
- 1,150 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q6PHZ2
- Ligands
- D0S
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 290 | — | Q6PHZ2 |
| B | — | protein | 285 | — | Q6PHZ2 |
| C | — | protein | 284 | — | Q6PHZ2 |
| D | — | protein | 291 | — | Q6PHZ2 |
Ligands and binding sites
- D0S · N-[(2S)-2-(diethylamino)propyl]-2-(3-hydroxyazetidin-1-yl)-6-[5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl]pyridine-4-carboxamide · ligand · 4 copies · chains A, B, C, D
- TLA · L(+)-tartaric acid · additive · 3 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6BAB · The structure of human CamKII with bound inhibitor · the same entry in another collection · chain D against D, TM-score 1.00
- Q6PHZ2 · AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type II… · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PHZ2
- Elsewhere: RCSB PDB 6BAB · PDBe 6BAB · UniProt Q6PHZ2
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