MolNFT v1 · #143722 · protein
Cryo-EM structure of human insulin degrading enzyme in complex with Fab H11 heavy chain and Fab H11 light chain
6B7Z · Insulin-degrading enzyme: “Cryo-EM structure of human insulin degrading enzyme in complex with Fab H11 heavy chain and Fab H11 light…”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #143722 on GenesisL1: 3D…
- PDB
- 6B7Z
- Type
- protein
- Length
- 2,744 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-degrading enzyme; Fab H11 heavy chain; Fab H11 light chain
- EC
- 3.4.24.56
- UniProt
- P14735, P0DOX5, Q6GMX0
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 4 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-degrading enzyme (EC 3.4.24.56) | protein | 949 | 41% helix, 14% strand | P14735 |
| B | Insulin-degrading enzyme (EC 3.4.24.56) | protein | 939 | 41% helix, 14% strand | P14735 |
| C, E | Fab H11 heavy chain | protein | 217 | 3% helix, 46% strand | P0DOX5 |
| D, F | Fab H11 light chain | protein | 211 | 4% helix, 44% strand | Q6GMX0 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 737 | 0.86 | 0.89 | 96 | empty |
| 2 | 571 | 0.86 | 0.91 | 82 | empty |
| 3 | 439 | 0.83 | 0.90 | 62 | empty |
| 4 | 351 | 0.83 | 0.92 | 61 | empty |
| 5 | 482 | 0.83 | 0.90 | 65 | empty |
Interfaces
7 interfaces between chains.
- E–F · 1995 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1767 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1161 Ų buried · 13 hydrogen bonds · protein-protein
- B–E · 718 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 684 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6B7Z · Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14735
- Every structure of UniProt P0DOX5
- Every structure of UniProt Q6GMX0
- Elsewhere: RCSB PDB 6B7Z · PDBe 6B7Z · UniProt P14735 · UniProt P0DOX5 · UniProt Q6GMX0
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