MolNFT v1 · #14371 · protein
Crystal structure of human pnp at 2.3A resolution
1M73 · Purine nucleoside phosphorylase: “Crystal structure of human pnp at 2.3A resolution”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.63). MolNFT v1 #14371 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1M73
- Type
- protein
- Length
- 288 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Purine nucleoside phosphorylase
- EC
- 2.4.2.1
- UniProt
- P00491
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Purine nucleoside phosphorylase (EC 2.4.2.1) | protein | 288 | 32% helix, 23% strand | P00491 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 366 | 0.63 | 0.79 | 49 | SO4 |
| 2 | 53 | 0.35 | 0.79 | 16 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00491
- Elsewhere: RCSB PDB 1M73 · PDBe 1M73 · UniProt P00491
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