MolNFT v1 · #143706 · protein
Structure of MGLUR3 with an agonist
6B7H · Metabotropic glutamate receptor 3: “Structure of MGLUR3 with an agonist”. X-ray diffraction, 3 ligands (CWY, NAG, CA), 4 pockets (best druggability 0.66). MolNFT v1 #143706 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6B7H
- Type
- protein
- Length
- 441 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor 3
- UniProt
- Q14832
- Ligands
- CWY, NAG, CA
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metabotropic glutamate receptor 3 | protein | 441 | 35% helix, 20% strand | Q14832 |
Ligands and binding sites
- CWY · (1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 194 | 0.66 | 0.85 | 36 | CWY |
| 2 | 84 | 0.64 | 0.90 | 19 | empty |
| 3 | 337 | 0.59 | 0.77 | 38 | empty |
| 4 | 51 | 0.35 | 0.79 | 17 | empty |
Modifications
Observed in the structure: 3 disulfide, 3 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14832
- Elsewhere: RCSB PDB 6B7H · PDBe 6B7H · UniProt Q14832
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