MolNFT v1 · #143697 · protein
Structures of the two-chain human plasma factor xiia co-crystallized with potent inhibitors
6B77: “Structures of the two-chain human plasma factor xiia co-crystallized with potent inhibitors”. X-ray diffraction, 4 ligands (CWV, NAG, SO4). MolNFT v1 #143697 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6B77
- Type
- protein
- Length
- 252 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P00748
- Ligands
- CWV, NAG, SO4, IOD
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 9 | — | P00748 |
| B | — | protein | 243 | — | P00748 |
Ligands and binding sites
- CWV · [3-(1-aminoisoquinolin-6-yl)phenyl]boronic acid · ligand · chains B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains B
- SO4 · Sulfate ion · ion · 3 copies · chains B
- IOD · Iodide ion · ion · 2 copies · chains B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6B77 · Structures of the two-chain human plasma factor XIIa co-crystallized with potent… · the same entry in another collection · chain A against A, TM-score 1.00
- P00748 · AlphaFold monomer V2.0 prediction for coagulation factor XII (P00748) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00748
- Elsewhere: RCSB PDB 6B77 · PDBe 6B77 · UniProt P00748
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.