UniProt P00748
Coagulation factor XII (P00748)
Coagulation factor XII (UniProt P00748), EC 3.4.21.38: 26 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 14 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00748
- Protein
- Coagulation factor XII
- EC
- 3.4.21.38
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 14 · 3 records with a druggable one
Structures
27 records of P00748 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4BDW | The structure of the FnI-EGF tandem domain of coagulation factor XII in complex with Holmium | x-ray diffraction | A | — | — |
| 4BDW | The structure of the fni-EGF tandem domain of coagulation factor XII in complex with holmium | x-ray diffraction | A | — | — |
| 4BDX | The structure of the FnI-EGF tandem domain of coagulation factor XII | x-ray diffraction | A | — | — |
| 4BDX | The structure of the fni-EGF tandem domain of coagulation factor XII | x-ray diffraction | A | — | — |
| 4XDE | Coagulation Factor XII protease domain crystal structure | x-ray diffraction | A | — | — |
| 4XDE | Coagulation factor XII protease domain crystal structure | x-ray diffraction | A | — | — |
| 4XE4 | Coagulation Factor XII protease domain crystal structure | x-ray diffraction | A | — | — |
| 4XE4 | Coagulation factor XII protease domain crystal structure | x-ray diffraction | A | — | — |
| 6B74 | Structures of the two-chain human plasma Factor XIIa co-crystallized with potent inhibitors | x-ray diffraction | A, B | NAG, BEN, IOD, SO4 | — |
| 6B74 | Structures of the two-chain human plasma factor xiia co-crystallized with potent inhibitors | x-ray diffraction | A, B | NAG, BEN, IOD, SO4 | — |
| 6B77 | Structures of the two-chain human plasma factor xiia co-crystallized with potent inhibitors | x-ray diffraction | A, B | NAG, CWV, IOD, SO4 | — |
| 6GT6 | Crystal structure of recombinant coagulation factor beta-XIIa | x-ray diffraction | B | NAG, SO4 | — |
| 6GT6 | Crystal structure of recombinant coagulation factor beta-xiia | x-ray diffraction | B | NAG, SO4 | — |
| 6L63 | Human Coagulation Factor XIIa (FXIIa) bound with the macrocyclic peptide F3 containing two… | x-ray diffraction | A, C | NAG, ACE | — |
| 6L63 | Human coagulation factor xiia (fxiia) bound with the macrocyclic peptide F3 containing two… | x-ray diffraction | A, C | NAG, ACE | — |
| 6QF7 | Crystal structures of the recombinant beta-factor xiia protease with bound thr-arg and pro-arg… | x-ray diffraction | B, D | NAG | — |
| 6SZW | Asymmetric complex of Factor XII and kininogen with gC1qR/C1QBP/P32 is governed by allostery | x-ray diffraction | D | — | 2 (best 0.49) |
| 6SZW | Asymmetric complex of factor XII and kininogen with GC1QR/C1QBP/P32 is governed by allostery | x-ray diffraction | D | — | — |
| 6X0S | Structure of human plasma factor XIIa in complex with… | x-ray diffraction | A, B, C | UJA, SO4 | 4 (best 0.75) |
| 6X0S | Structure of human plasma factor xiia in complex with (2S)-4-(5… | x-ray diffraction | A, B, C | UJA, SO4 | — |
| 6X0T | Structure of human plasma factor XIIa in complex with… | x-ray diffraction | A, B, C | UJ7, SO4 | 4 (best 0.75) |
| 6X0T | Structure of human plasma factor xiia in complex with (2S)-1-(N,3… | x-ray diffraction | A, B, C | UJ7, SO4 | — |
| 7FBP | Fxiia-CMCOFX1 complex | x-ray diffraction | A | NAG, MAN | — |
| 7PRJ | Factor XII Fibronectin type II (FXII FnII) domain | x-ray diffraction | A | ZN | — |
| 7PRK | Factor XII Fibronectin type II (FXII FnII) domain | x-ray diffraction | A | ZN | — |
| 8R8D | Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment… | electron microscopy | B, A | NAG, MAN, FUC | 4 (best 0.81) |
| P00748 | AlphaFold monomer V2.0 prediction for coagulation factor XII (P00748) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 10 records
- SO4 · Sulfate ion · in 9 records
- IOD · Iodide ion · in 3 records
- ACE · Acetyl group · in 2 records
- BEN · Benzamidine · in 2 records
- MAN · alpha-D-mannopyranose · in 2 records
- UJ7 · (2S)-1-(N,3-dicyclohexyl-D-alanyl)-4-[(4R,5S)-4-methyl-5-phenyl-4,5-dihydro-1,3-oxazol-2-yl]-N-[(thiophen-2-yl)methyl]piperazine-2-carboxamide · in 2 records
- UJA · (2S)-4-(5-chloro-1,3-benzoxazol-2-yl)-1-(N,3-dicyclohexyl-D-alanyl)-N-[(thiophen-2-yl) methyl]piperazine-2-carboxamide · in 2 records
- ZN · Zinc ion · in 2 records
- CWV · [3-(1-aminoisoquinolin-6-yl)phenyl]boronic acid · in 1 record
- FUC · alpha-L-fucopyranose · in 1 record
Experiment against prediction
- 8R8D chain A against the predicted model P00748: TM-score 0.98, RMSD 0.96 Å
- 8R8D chain B against the predicted model P00748: TM-score 0.98, RMSD 0.96 Å
- 6L63 chain A against the predicted model P00748: TM-score 0.97, RMSD 1.03 Å
- 6L63 chain A against the predicted model P00748: TM-score 0.97, RMSD 1.03 Å
- 6L63 chain C against the predicted model P00748: TM-score 0.97, RMSD 1.09 Å
- 6L63 chain C against the predicted model P00748: TM-score 0.97, RMSD 1.09 Å
- 6X0S chain B against the predicted model P00748: TM-score 0.97, RMSD 1.13 Å
- 6X0S chain B against the predicted model P00748: TM-score 0.97, RMSD 1.13 Å
- 6X0S chain C against the predicted model P00748: TM-score 0.97, RMSD 1.13 Å
- 6X0S chain C against the predicted model P00748: TM-score 0.97, RMSD 1.13 Å
Elsewhere
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