MolNFT v1 · #143584 · protein
Structure of HS/ACPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1, 2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl) methyl]-3,4-dihydroisoquinolin-1(2H)-one
6B3W: “Structure of HS/ACPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1…”. X-ray diffraction, 2 ligands (CJG, ZN). MolNFT v1 #143584 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6B3W
- Type
- protein
- Length
- 1,901 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- G1KPH4, O75530, Q15022
- Ligands
- CJG, ZN
Structure
x-ray diffraction · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 463 | — | G1KPH4 |
| B | — | protein | 465 | — | G1KPH4 |
| E | — | protein | 358 | — | O75530 |
| F | — | protein | 359 | — | O75530 |
| S, T | — | protein | 128 | — | Q15022 |
Ligands and binding sites
- CJG · 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one · ligand · 2 copies · chains A, B
- ZN · Zinc ion · metal · 14 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6B3W · Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4… · the same entry in another collection · chain T against T, TM-score 1.00
- O75530 · AlphaFold monomer V2.0 prediction for polycomb protein eed (O75530) · a predicted model of the same protein · chain E against A, TM-score 0.99
- Q15022 · AlphaFold monomer V2.0 prediction for polycomb protein SUZ12 (Q15022) · a predicted model of the same protein · chain S against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G1KPH4
- Every structure of UniProt O75530
- Every structure of UniProt Q15022
- Elsewhere: RCSB PDB 6B3W · PDBe 6B3W · UniProt G1KPH4 · UniProt O75530 · UniProt Q15022
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