UniProt G1KPH4
Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2 (G1KPH4)
Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2 (UniProt G1KPH4), EC 2.1.1.43: 8 experimental structures on GenesisL1, 3 ligands bound, 37 pockets. Binding sites, pockets, druggability and 3D structures…
- UniProt
- G1KPH4
- Protein
- Enhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2
- EC
- 2.1.1.43
- Experimental structures
- 8
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 37 · 2 records with a druggable one
Structures
8 records of G1KPH4 in the MolNFT archive: 8 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4W2R | Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin… | x-ray diffraction | A, B | — | — |
| 4W2R | Structure of HS/ACPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6… | x-ray diffraction | A, B | — | — |
| 5IJ7 | Structure of Hs/AcPRC2 in complex with a pyridone inhibitor | x-ray diffraction | A, B | 6BN, ZN | — |
| 5IJ7 | Structure of HS/ACPRC2 in complex with a pyridone inhibitor | x-ray diffraction | A, B | — | — |
| 5IJ8 | Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor | x-ray diffraction | A, B | 6BN, ZN | 18 (best 0.87) |
| 5IJ8 | Structure of the primary oncogenic mutant Y641N HS/ACPRC2 in complex with a pyridone inhibitor | x-ray diffraction | A, B | — | — |
| 6B3W | Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethy… | x-ray diffraction | A, B | ZN, CJG | 19 (best 0.86) |
| 6B3W | Structure of HS/ACPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1… | x-ray diffraction | A, B | ZN, CJG | — |
Ligands
- ZN · Zinc ion · in 4 records
- 6BN · 5,8-dichloro-2-[(4-ethyl-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-({1-[(2R)-2-hydroxypropanoyl]piperidin-4-yl}oxy)-3,4-dihydroisoquinolin-1(2H)-one · in 2 records
- CJG · 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one · in 2 records
Experiment against prediction
- 5IJ8 chain B against the predicted model Q15910: TM-score 0.95, RMSD 2.15 Å
- 5IJ8 chain B against the predicted model Q15910: TM-score 0.95, RMSD 2.15 Å
- 5IJ7 chain B against the predicted model Q15910: TM-score 0.95, RMSD 2.18 Å
- 5IJ7 chain B against the predicted model Q15910: TM-score 0.95, RMSD 2.18 Å
- 5IJ7 chain A against the predicted model Q15910: TM-score 0.93, RMSD 2.73 Å
- 5IJ7 chain A against the predicted model Q15910: TM-score 0.93, RMSD 2.73 Å
- 5IJ8 chain A against the predicted model Q15910: TM-score 0.93, RMSD 2.76 Å
- 5IJ8 chain A against the predicted model Q15910: TM-score 0.93, RMSD 2.76 Å
Elsewhere
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