MolNFT v1 · #143176 · protein
Structure of cetuximab Fab mutant in complex with EGFR extracellular domain
6ARU: “Structure of cetuximab Fab mutant in complex with EGFR extracellular domain”. X-ray diffraction, 3 ligands (NAG, MAN, BMA). MolNFT v1 #143176 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ARU
- Type
- protein
- Length
- 1,031 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P00533, Q8TCD0, P0DOX5
- Ligands
- NAG, MAN, BMA
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 609 | — | P00533 |
| B | — | protein | 210 | — | Q8TCD0 |
| C | — | protein | 212 | — | P0DOX5 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 7 copies · chains A, C
- MAN · alpha-D-mannopyranose · sugar · 5 copies · chains A
- BMA · beta-D-mannopyranose · sugar · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6ARU · Structure of Cetuximab Fab mutant in complex with EGFR extracellular domain · the same entry in another collection · chain A against A, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Every structure of UniProt Q8TCD0
- Every structure of UniProt P0DOX5
- Elsewhere: RCSB PDB 6ARU · PDBe 6ARU · UniProt P00533 · UniProt Q8TCD0 · UniProt P0DOX5
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