MolNFT v1 · #143101 · protein
Crystal structure of rsv F bound by AM22 and the infant antibody adi- 19425
6APD · Fusion glycoprotein F0,ENVELOPE glycoprotein: “Crystal structure of rsv F bound by AM22 and the infant antibody adi- 19425”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #143101 on GenesisL1: 3D structure…
- PDB
- 6APD
- Type
- protein
- Length
- 3,968 residues
- Chains
- 15
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0,ENVELOPE glycoprotein; AM22 Fab heavy CHAIN,IGH@ protein; AM22 Fab…
- UniProt
- C3UPB8, M1E1E4, Q6GMX6, Q8TCD0, A0A0B4J1V1, P0DOX5, Q6GMX4
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 10 distinct chains · 18% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion glycoprotein F0,ENVELOPE glycoprotein | protein | 451 | 32% helix, 33% strand | C3UPB8, M1E1E4 |
| B | Fusion glycoprotein F0,ENVELOPE glycoprotein | protein | 453 | 33% helix, 33% strand | C3UPB8, M1E1E4 |
| C | Fusion glycoprotein F0,ENVELOPE glycoprotein | protein | 452 | 32% helix, 33% strand | C3UPB8, M1E1E4 |
| D, H | AM22 Fab heavy CHAIN,IGH@ protein | protein | 221 | 3% helix, 53% strand | Q6GMX6 |
| E | AM22 Fab light CHAIN,UNCHARACTERIZED protein | protein | 213 | 7% helix, 52% strand | Q8TCD0 |
| F | AM22 Fab heavy CHAIN,IGH@ protein | protein | 222 | 4% helix, 53% strand | Q6GMX6 |
| G | AM22 Fab light CHAIN,UNCHARACTERIZED protein | protein | 215 | 7% helix, 52% strand | Q8TCD0 |
| I | AM22 Fab light CHAIN,UNCHARACTERIZED protein | protein | 212 | 7% helix, 52% strand | Q8TCD0 |
| J, K, N | Immunoglobulin heavy variable 3-21,IMMUNOGLOBULIN gamma-1 heavy chain | protein | 223 | 8% helix, 49% strand | A0A0B4J1V1, P0DOX5 |
| L, M, O | Igl@ protein | protein | 213 | 8% helix, 51% strand | Q6GMX4 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1124 | 0.84 | 0.85 | 114 | empty |
| 2 | 1100 | 0.84 | 0.85 | 110 | empty |
| 3 | 1067 | 0.84 | 0.85 | 83 | empty |
| 4 | 888 | 0.80 | 0.83 | 77 | empty |
| 5 | 110 | 0.79 | 0.98 | 34 | empty |
Interfaces
30 interfaces between chains.
- A–B · 2400 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 2352 Ų buried · 17 hydrogen bonds · protein-protein
- B–C · 2344 Ų buried · 21 hydrogen bonds · protein-protein
- F–G · 1955 Ų buried · 12 hydrogen bonds · protein-protein
- N–O · 1922 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 49 disulfide (disulfide).
Compared structures
- 6APD · Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C3UPB8
- Every structure of UniProt M1E1E4
- Every structure of UniProt Q6GMX6
- Every structure of UniProt Q8TCD0
- Every structure of UniProt A0A0B4J1V1
- Every structure of UniProt P0DOX5
- Every structure of UniProt Q6GMX4
- Elsewhere: RCSB PDB 6APD · PDBe 6APD · UniProt C3UPB8 · UniProt M1E1E4 · UniProt Q6GMX6 · UniProt Q8TCD0 · UniProt A0A0B4J1V1 · UniProt P0DOX5 · UniProt Q6GMX4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.