UniProt M1E1E4
Spike glycoprotein,Envelope glycoprotein (M1E1E4)
Spike glycoprotein,Envelope glycoprotein (UniProt M1E1E4): 47 experimental structures on GenesisL1, 12 ligands bound, 243 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- M1E1E4
- Protein
- Spike glycoprotein,Envelope glycoprotein
- Experimental structures
- 47
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 243 · 17 records with a druggable one
Structures
47 records of M1E1E4 in the MolNFT archive: 47 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2M7W | Independently verified structure of gp41-M-MAT, a membrane associated MPER trimer from HIV-1 gp41 | solution nmr | A, B, C | — | — |
| 2M7W | Independently verified structure of GP41-M-mat, a membrane associated mper trimer from HIV-1 GP41 | solution nmr | A, B, C | — | — |
| 5KWW | Crystal Structure of Inhibitor JNJ-53718678 In Complex with Prefusion RSV F Glycoprotein | x-ray diffraction | F | NAG, SO4, 6YA | 2 (best 0.45) |
| 5KWW | Crystal structure of inhibitor jnj-53718678 in complex with prefusion rsv F glycoprotein | x-ray diffraction | F | NAG, SO4, 6YA | — |
| 5U68 | Structural basis for antibody cross-neutralization of respiratory syncytial virus and human… | x-ray diffraction | A, B, C | — | 17 (best 0.85) |
| 5U68 | Structural basis for antibody cross-neutralization of respiratory syncytial virus and human… | x-ray diffraction | A, B, C | — | — |
| 6A0Z | Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, HA… | x-ray diffraction | A | NAG | — |
| 6A0Z | Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, ha… | x-ray diffraction | A | NAG | — |
| 6APD | Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425 | x-ray diffraction | A, B, C | — | — |
| 6APD | Crystal structure of rsv F bound by AM22 and the infant antibody adi- 19425 | x-ray diffraction | A, B, C | — | — |
| 6CNV | Influenza B/BRISBANE hemagglutinin Fab CR9115 SD84H complex | x-ray diffraction | B | NAG | 5 (best 0.62) |
| 6CNV | Influenza B/BRISBANE hemagglutinin Fab CR9115 SD84H complex | x-ray diffraction | B | NAG | — |
| 6CXC | 3.9A Cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus… | electron microscopy | A, B, C, D, E, F | NAG | 18 (best 0.84) |
| 6CXC | 3.9A cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus… | electron microscopy | A, B, C, D, E, F | NAG | — |
| 6DC3 | RSV prefusion F bound to RSD5 Fab | x-ray diffraction | F | NAG, SO4 | 4 (best 0.53) |
| 6DC3 | Rsv prefusion F bound to RSD5 Fab | x-ray diffraction | F | NAG, SO4 | — |
| 6DC5 | RSV prefusion F in complex with AM22 Fab | x-ray diffraction | A, D, G | NAG, CD | 14 (best 0.82) |
| 6DC5 | Rsv prefusion F in complex with AM22 Fab | x-ray diffraction | A, D, G | NAG, CD | — |
| 6G9I | Crystal structure of Ebolavirus glycoprotein in complex with clomipramine | x-ray diffraction | B | NAG, CXX | 4 (best 0.56) |
| 6G9I | Crystal structure of ebolavirus glycoprotein in complex with clomipramine | x-ray diffraction | B | NAG, CXX | — |
| 6ONA | Crystal structure of Influenza hemagglutinin from strain A/Hickox/JY2/1940 | x-ray diffraction | A, B, C | NAG, CL | 12 (best 0.85) |
| 6ONA | Crystal structure of influenza hemagglutinin from strain A/HICKOX/JY2/1940 | x-ray diffraction | A, B, C | NAG, CL | — |
| 6OUS | Structure of fusion glycoprotein from human respiratory syncytial virus | x-ray diffraction | B, D, F, H, J, L | NAG | 20 (best 0.84) |
| 6OUS | Structure of fusion glycoprotein from human respiratory syncytial virus | x-ray diffraction | B, D, F, H, J, L | NAG | — |
| 6VKC | Crystal Structure of Inhibitor JNJ-36811054 in Complex with Prefusion RSV F Glycoprotein | x-ray diffraction | F | NAG, FUC, CL, SO4, R0J | 2 (best 0.29) |
| 6VKC | Crystal structure of inhibitor jnj-36811054 in complex with prefusion rsv F glycoprotein | x-ray diffraction | F | NAG, FUC, CL, SO4, R0J | — |
| 6VKD | Crystal Structure of Inhibitor JNJ-36689282 in Complex with Prefusion RSV F Glycoprotein | x-ray diffraction | F | R0P, CL, SO4 | 2 (best 0.30) |
| 6VKD | Crystal structure of inhibitor jnj-36689282 in complex with prefusion rsv F glycoprotein | x-ray diffraction | F | R0P, CL, SO4 | — |
| 6VKE | Crystal Structure of Inhibitor JNJ-40012665 in Complex with Prefusion RSV F Glycoprotein | x-ray diffraction | F | R0S, CL, SO4 | 2 (best 0.37) |
| 6VKE | Crystal structure of inhibitor jnj-40012665 in complex with prefusion rsv F glycoprotein | x-ray diffraction | F | R0S, CL, SO4 | — |
| 6W16 | Crystal structure of a human metapneumovirus monomeric fusion protein complexed with 458 Fab | x-ray diffraction | F | NAG | 6 (best 0.66) |
| 6W16 | Crystal structure of a human metapneumovirus monomeric fusion protein complexed with 458 Fab | x-ray diffraction | F | NAG | — |
| 7AD1 | Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and… | electron microscopy | A, B, C | NAG | 20 (best 0.86) |
| 7AD1 | Cryo-EM structure of a prefusion stabilized SARS-cov-2 spike (D614N, R682S, R685G, A892P, A942P and… | electron microscopy | A, B, C | NAG | — |
| 7FJN | Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6… | electron microscopy | A, B, C | NAG | 20 (best 0.84) |
| 7FJN | Cryo-EM structure of south african (B.1.351) SARS-cov-2 spike glycoprotein in complex with two T6… | electron microscopy | A, B, C | NAG | — |
| 7KC1 | Cryo-EM structure of SRR2899884.46167H+MEDI8852L fab in complex with Victoria HA | electron microscopy | B, D, I | NAG | 20 (best 0.80) |
| 7KC1 | Cryo-EM structure of SRR2899884.46167H+MEDI8852L Fab in complex with victoria ha | electron microscopy | B, D, I | NAG | — |
| 7L7F | Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1 | electron microscopy | E, F | — | 7 (best 0.73) |
| 7L7F | Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162B1 | electron microscopy | E, F | — | — |
| 7MPG | Cryo-EM structure of Prefusion-stabilized RSV F (DS-Cav1) in complex with Fab AM14 | electron microscopy | A, B, C | NAG | 17 (best 0.81) |
| 7MPG | Cryo-EM structure of prefusion-stabilized rsv F (ds-CAV1) in complex with Fab AM14 | electron microscopy | A, B, C | NAG | — |
| 7QTI | SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global) | electron microscopy | D, K, A | NAG, BMA | 18 (best 0.88) |
| 7QTI | SARS-cov-2 S omicron spike B.1.1.529 - 3-P2G3 and 1-P5C3 fabs (global) | electron microscopy | D, K, A | NAG | — |
| 7ZRV | cryo-EM structure of omicron spike in complex with de novo designed binder, full map | electron microscopy | A, B, C | NAG | 20 (best 0.86) |
| 8HFX | Cryo-EM structure of SARS-CoV-2 Omicron BA.1 spike protein in complex with white-tailed deer ACE2 | electron microscopy | A, B, C | NAG | 12 (best 0.88) |
| 9BJM | Crystal Structure of Inhibitor 5c in Complex with Prefusion RSV F Glycoprotein | x-ray diffraction | A | A1APZ | 1 (best 0.31) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 34 records
- SO4 · Sulfate ion · in 10 records
- CL · Chloride ion · in 8 records
- 6YA · 3-[[5-chloranyl-1-(3-methylsulfonylpropyl)indol-2-yl]methyl]-1-[2,2,2-tris(fluoranyl)ethyl]imidazo[4,5-c]pyridin-2-one · in 2 records
- CD · Cadmium ion · in 2 records
- CXX · 3-(3-chloro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine · in 2 records
- FUC · alpha-L-fucopyranose · in 2 records
- R0J · 3-{[5-chloro-1-(4,4,4-trifluorobutyl)-1H-imidazo[4,5-b]pyridin-2-yl]methyl}-1-cyclopropyl-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one · in 2 records
- R0P · 1-cyclopropyl-3-({1-[3-(methylsulfonyl)propyl]-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one · in 2 records
- R0S · 4-(5-chloro-2-{[1-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydro-3H-imidazo[4,5-c]pyridin-3-yl]methyl}-1H-indol-1-yl)butanenitrile · in 2 records
- A1APZ · 1'-{[5-chloro-1-(4,4,4-trifluorobutyl)-1H-1,3-benzimidazol-2-yl]methyl}-1-(methanesulfonyl)spiro[azetidine-3,3'-indol]-2'(1'H)-one · in 1 record
- BMA · beta-D-mannopyranose · in 1 record
Elsewhere
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