MolNFT v1 · #142749 · protein
Structure insight into histone chaperone CHZ1-mediated H2A.Z recognition and replacement
6AE8 · Histone H2B.1,HISTONE H2A.Z: “Structure insight into histone chaperone CHZ1-mediated H2A.Z recognition and replacement”. X-ray diffraction, 1 ligand (BCN), 7 pockets (best druggability 0.54). MolNFT v1 #142749 on GenesisL1: 3D…
- PDB
- 6AE8
- Type
- protein
- Length
- 388 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H2B.1,HISTONE H2A.Z; Histone H2A.Z-specific chaperone CHZ1
- UniProt
- P02293, Q12692, P40019
- Ligands
- BCN
- Pockets
- 7 · best druggability 0.54
Structure
x-ray diffraction · 4 distinct chains · 67% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone H2B.1,HISTONE H2A.Z | protein | 182 | 70% helix, 5% strand | P02293, Q12692 |
| C | Histone H2A.Z-specific chaperone CHZ1 | protein | 12 | 25% helix, 8% strand | P40019 |
| B | Histone H2B.1,HISTONE H2A.Z | protein | 182 | 70% helix, 5% strand | P02293, Q12692 |
| D | Histone H2A.Z-specific chaperone CHZ1 | protein | 12 | 25% helix, 8% strand | P40019 |
Ligands and binding sites
- BCN · Bicine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 294 | 0.54 | 0.75 | 35 | empty |
| 2 | 221 | 0.52 | 0.77 | 23 | empty |
| 3 | 146 | 0.49 | 0.78 | 19 | empty |
| 4 | 96 | 0.39 | 0.76 | 18 | empty |
| 5 | 76 | 0.35 | 0.76 | 16 | empty |
Interfaces
4 interfaces between chains.
- A–B · 688 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 543 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 543 Ų buried · 21 hydrogen bonds · protein-protein
- C–B · 38 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6AE8 · Structure insight into histone chaperone Chz1-mediated H2A.Z recognition and replacement · the same entry in another collection · chain A against A, TM-score 1.00
- P02293 · AlphaFold monomer V2.0 prediction for histone H2B.1 (P02293) · a predicted model of the same protein · chain A against A, TM-score 0.49
- Q12692 · AlphaFold monomer V2.0 prediction for histone H2A.Z (Q12692) · a predicted model of the same protein · chain A against A, TM-score 0.47
- P40019 · AlphaFold monomer V2.0 prediction for histone H2A.Z-specific chaperone CHZ1 (P40019) · a predicted model of the same protein · chain D against A, TM-score 0.38
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02293
- Every structure of UniProt Q12692
- Every structure of UniProt P40019
- Elsewhere: RCSB PDB 6AE8 · PDBe 6AE8 · UniProt P02293 · UniProt Q12692 · UniProt P40019
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.