MolNFT v1 · #142426 · protein

R1EN(5-223)-ubiquitin fusion

6A42 · RNA-directed DNA polymerase homolog (R1),POLYUBIQUITIN-C: “R1EN(5-223)-ubiquitin fusion”. X-ray diffraction, 2 pockets (best druggability 0.55). MolNFT v1 #142426 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6A42
Type: protein
Length: 293 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed DNA polymerase homolog (R1),POLYUBIQUITIN-C
EC: 2.7.7.49
UniProt: Q7M4J4, P0CH28
Pockets: 2 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 23% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed DNA polymerase homolog (R1),POLYUBIQUITIN-C (EC 2.7.7.49)	protein	293	23% helix, 32% strand	Q7M4J4, P0CH28

Ligands and binding sites

ACY · Acetic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	289	0.55	0.76	33	empty
2	150	0.41	0.74	24	empty

Compared structures

6A42 · R1EN(5-223)-ubiquitin fusion · the same entry in another collection · chain A against A, TM-score 1.00
P0CH28 · AlphaFold monomer V2.0 prediction for polyubiquitin-C (P0CH28) · a predicted model of the same protein · chain A against A, TM-score 0.31

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7M4J4
Every structure of UniProt P0CH28
Elsewhere: RCSB PDB 6A42 · PDBe 6A42 · UniProt Q7M4J4 · UniProt P0CH28

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.