MolNFT v1 · #142255 · protein
The structure of human PAF1/CTR9 complex
5ZYQ · RNA polymerase-associated protein CTR9 HOMOLOG,RNA…: “The structure of human PAF1/CTR9 complex”. X-ray diffraction, 3 pockets (best druggability 0.58). MolNFT v1 #142255 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5ZYQ
- Type
- protein
- Length
- 285 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA polymerase-associated protein CTR9 HOMOLOG,RNA polymerase II-associated factor 1…
- UniProt
- Q6PD62, Q8N7H5
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 1 distinct chain · 63% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA polymerase-associated protein CTR9 HOMOLOG,RNA polymerase II-associated factor 1 homolog | protein | 285 | 63% helix, 4% strand | Q6PD62, Q8N7H5 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 195 | 0.58 | 0.81 | 34 | empty |
| 2 | 92 | 0.45 | 0.80 | 14 | empty |
| 3 | 130 | 0.43 | 0.76 | 23 | empty |
Compared structures
- 5ZYQ · The Structure of Human PAF1/CTR9 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q6PD62 · AlphaFold monomer V2.0 prediction for RNA polymerase-associated protein CTR9 homolog… · a predicted model of the same protein · chain A against A, TM-score 0.81
- Q8N7H5 · AlphaFold monomer V2.0 prediction for RNA polymerase II-associated factor 1 homolog… · a predicted model of the same protein · chain A against A, TM-score 0.27
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PD62
- Every structure of UniProt Q8N7H5
- Elsewhere: RCSB PDB 5ZYQ · PDBe 5ZYQ · UniProt Q6PD62 · UniProt Q8N7H5
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