UniProt Q8N7H5
RNA polymerase II-associated factor 1 homolog (Q8N7H5)
RNA polymerase II-associated factor 1 homolog (UniProt Q8N7H5): 22 experimental structures and 1 predicted model on GenesisL1, 36 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8N7H5
- Protein
- RNA polymerase II-associated factor 1 homolog
- Experimental structures
- 22
- Predicted models
- 1
- Pockets
- 36 · 11 records with a druggable one
Structures
23 records of Q8N7H5 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4M6T | Structure of human Paf1 and Leo1 complex | x-ray diffraction | A | — | — |
| 4M6T | Structure of human PAF1 and LEO1 complex | x-ray diffraction | A | — | — |
| 5ZYQ | The Structure of Human PAF1/CTR9 complex | x-ray diffraction | A | — | 3 (best 0.58) |
| 5ZYQ | The structure of human PAF1/CTR9 complex | x-ray diffraction | A | — | — |
| 6GMH | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | electron microscopy | V | — | — |
| 6GMH | Structure of activated transcription complex pol II-dsif-paf-SPT6 | electron microscopy | V | — | — |
| 6TED | Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric… | electron microscopy | V | — | 5 (best 0.84) |
| 6TED | Structure of complete, activated transcription complex pol II-dsif- paf-SPT6 uncovers allosteric… | electron microscopy | V | — | — |
| 7OOP | Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) | electron microscopy | V | — | — |
| 7OOP | Pol II-csb-csa-DDB1-uvssa-paf-SPT6 (structure 3) | electron microscopy | V | — | — |
| 7OPC | Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 4) | electron microscopy | V | — | — |
| 7OPC | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 4) | electron microscopy | V | — | — |
| 7OPD | Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 5) | electron microscopy | V | — | — |
| 7OPD | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 5) | electron microscopy | V | — | — |
| 7UNC | Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | electron microscopy | V | — | 1 (best 0.85) |
| 7UND | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | electron microscopy | V | — | 3 (best 0.81) |
| 8A3Y | Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex | electron microscopy | V | — | 4 (best 0.84) |
| 9EGX | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 | electron microscopy | V | — | 4 (best 0.84) |
| 9EGY | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | electron microscopy | V | — | 4 (best 0.85) |
| 9EGZ | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27 | electron microscopy | V | — | 3 (best 0.84) |
| 9EH0 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, 30 bp upstream | electron microscopy | V | — | 3 (best 0.84) |
| 9EH2 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream | electron microscopy | V | — | 3 (best 0.83) |
| Q8N7H5 | AlphaFold monomer V2.0 prediction for RNA polymerase II-associated factor 1 homolog (Q8N7H5) | predicted | A | — | 3 (best 0.60) |
Experiment against prediction
- 5ZYQ chain A against the predicted model Q6PD62: TM-score 0.81, RMSD 1.94 Å
- 5ZYQ chain A against the predicted model Q6PD62: TM-score 0.81, RMSD 1.94 Å
- 6GMH chain V against the predicted model Q8N7H5: TM-score 0.62, RMSD 3.15 Å
- 6GMH chain V against the predicted model Q8N7H5: TM-score 0.62, RMSD 3.15 Å
- 6TED chain V against the predicted model Q8N7H5: TM-score 0.37, RMSD 4.77 Å
- 6TED chain V against the predicted model Q8N7H5: TM-score 0.37, RMSD 4.77 Å
- 8A3Y chain V against the predicted model Q8N7H5: TM-score 0.37, RMSD 4.77 Å
- 9EH2 chain V against the predicted model Q8N7H5: TM-score 0.37, RMSD 4.49 Å
- 9EGZ chain V against the predicted model Q8N7H5: TM-score 0.37, RMSD 4.47 Å
- 9EGY chain V against the predicted model Q8N7H5: TM-score 0.37, RMSD 4.47 Å
Elsewhere
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