MolNFT v1 · #141661 · protein
Crystal structure of the dimeric human pnpase
5ZF6 · Polyribonucleotide nucleotidyltransferase 1, mitochondrial: “Crystal structure of the dimeric human pnpase”. X-ray diffraction, 10 pockets (best druggability 0.62). MolNFT v1 #141661 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5ZF6
- Type
- protein
- Length
- 1,108 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polyribonucleotide nucleotidyltransferase 1, mitochondrial
- EC
- 2.7.7.8
- UniProt
- Q8TCS8
- Pockets
- 10 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) | protein | 560 | 39% helix, 29% strand | Q8TCS8 |
| B | Polyribonucleotide nucleotidyltransferase 1, mitochondrial (EC 2.7.7.8) | protein | 548 | 39% helix, 28% strand | Q8TCS8 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 402 | 0.62 | 0.77 | 42 | empty |
| 2 | 350 | 0.61 | 0.78 | 33 | empty |
| 3 | 461 | 0.59 | 0.74 | 52 | empty |
| 4 | 277 | 0.59 | 0.78 | 40 | empty |
| 5 | 441 | 0.57 | 0.74 | 50 | empty |
Interfaces
1 interface between chains.
- A–B · 1104 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TCS8
- Elsewhere: RCSB PDB 5ZF6 · PDBe 5ZF6 · UniProt Q8TCS8
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