MolNFT v1 · #141076 · protein
Crystal structure of karyopherin BETA2 in complex with FUS(456-526)
5YVI · Transportin-1: “Crystal structure of karyopherin BETA2 in complex with FUS(456-526)”. X-ray diffraction, 8 pockets (best druggability 0.48). MolNFT v1 #141076 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5YVI
- Type
- protein
- Length
- 847 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; RNA-binding protein fus
- UniProt
- Q92973, P35637
- Pockets
- 8 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 828 | 77% helix, 0% strand | Q92973 |
| B | RNA-binding protein fus | protein | 19 | 42% helix, 0% strand | P35637 |
Pockets
8 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.48 | 0.80 | 16 | empty |
| 2 | 67 | 0.43 | 0.81 | 19 | empty |
| 3 | 155 | 0.42 | 0.75 | 34 | empty |
| 4 | 142 | 0.41 | 0.75 | 23 | empty |
| 5 | 85 | 0.34 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1310 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 5YVI · Crystal structure of Karyopherin beta2 in complex with FUS(456-526) · the same entry in another collection · chain A against A, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P35637 · AlphaFold monomer V2.0 prediction for RNA-binding protein fus (P35637) · a predicted model of the same protein · chain B against A, TM-score 0.54
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt P35637
- Elsewhere: RCSB PDB 5YVI · PDBe 5YVI · UniProt Q92973 · UniProt P35637
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