MolNFT v1 · #141075 · protein
Crystal structure of karyopherin BETA2 in complex with FUS(371-526)
5YVH · Transportin-1: “Crystal structure of karyopherin BETA2 in complex with FUS(371-526)”. X-ray diffraction, 12 pockets (best druggability 0.56). MolNFT v1 #141075 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5YVH
- Type
- protein
- Length
- 828 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; RNA-binding protein fus
- UniProt
- Q92973, P35637
- Pockets
- 12 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 809 | 74% helix, 0% strand | Q92973 |
| B | RNA-binding protein fus | protein | 19 | 42% helix, 0% strand | P35637 |
Pockets
12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.56 | 0.86 | 18 | empty |
| 2 | 83 | 0.55 | 0.85 | 23 | empty |
| 3 | 179 | 0.50 | 0.77 | 21 | empty |
| 4 | 148 | 0.44 | 0.76 | 32 | empty |
| 5 | 159 | 0.44 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1340 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 5YVH · Crystal structure of Karyopherin beta2 in complex with FUS(371-526) · the same entry in another collection · chain A against A, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P35637 · AlphaFold monomer V2.0 prediction for RNA-binding protein fus (P35637) · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt P35637
- Elsewhere: RCSB PDB 5YVH · PDBe 5YVH · UniProt Q92973 · UniProt P35637
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