MolNFT v1 · #141074 · protein
Crystal structure of karyopherin BETA2 in complex with FUS(FULL length)
5YVG · Transportin-1: “Crystal structure of karyopherin BETA2 in complex with FUS(FULL length)”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #141074 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5YVG
- Type
- protein
- Length
- 1,626 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transportin-1; RNA-binding protein fus
- UniProt
- Q92973, P35637
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 4 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transportin-1 | protein | 830 | 72% helix, 0% strand | Q92973 |
| B | Transportin-1 | protein | 764 | 71% helix, 0% strand | Q92973 |
| X | RNA-binding protein fus | protein | 18 | 44% helix, 0% strand | P35637 |
| Y | RNA-binding protein fus | protein | 14 | 43% helix, 0% strand | P35637 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 934 | 0.80 | 0.81 | 102 | empty |
| 2 | 91 | 0.72 | 0.94 | 19 | empty |
| 3 | 586 | 0.71 | 0.80 | 65 | empty |
| 4 | 56 | 0.70 | 0.96 | 20 | empty |
| 5 | 108 | 0.69 | 0.91 | 39 | empty |
Interfaces
3 interfaces between chains.
- A–X · 1140 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1028 Ų buried · 9 hydrogen bonds · protein-protein
- B–Y · 700 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5YVG · Crystal structure of Karyopherin beta2 in complex with FUS(full length) · the same entry in another collection · chain Y against Y, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P35637 · AlphaFold monomer V2.0 prediction for RNA-binding protein fus (P35637) · a predicted model of the same protein · chain Y against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92973
- Every structure of UniProt P35637
- Elsewhere: RCSB PDB 5YVG · PDBe 5YVG · UniProt Q92973 · UniProt P35637
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.