MolNFT v1 · #139969 · protein
Crystal structure of transketolase in complex with hydroxylated tpp from pichia stipitis, crystal 2
5XVT: “Crystal structure of transketolase in complex with hydroxylated tpp from pichia stipitis, crystal 2”. X-ray diffraction, 2 ligands (8FL, CA), 4 pockets (best druggability 0.57). MolNFT v1 #139969 on GenesisL1: 3D structure, binding…
- PDB
- 5XVT
- Type
- protein
- Length
- 675 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transketolase
- EC
- 2.2.1.1
- UniProt
- P34736
- Ligands
- 8FL, CA
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transketolase (EC 2.2.1.1) | protein | 675 | 45% helix, 13% strand | P34736 |
Ligands and binding sites
- 8FL · 2-[(2R)-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-oxidanyl-2H-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate · ligand · chains A
- CA · Calcium ion · metal · chains A
- PEG · Di(hydroxyethyl)ether · additive · 7 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.57 | 0.77 | 37 | PEG |
| 2 | 83 | 0.51 | 0.84 | 17 | CA, 8FL |
| 3 | 104 | 0.37 | 0.74 | 17 | PEG |
| 4 | 63 | 0.30 | 0.74 | 16 | PEG |
Compared structures
- 5XVT · Crystal Structure of Transketolase in complex with hydroxylated TPP from Pichia Stipitis… · the same entry in another collection · chain A against A, TM-score 1.00
- P34736 · AlphaFold monomer V2.0 prediction for transketolase (P34736) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34736
- Elsewhere: RCSB PDB 5XVT · PDBe 5XVT · UniProt P34736
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