MolNFT v1 · #139246 · protein
Mismatch repair protein
5X9W · DNA mismatch repair protein muts: “Mismatch repair protein”. X-ray diffraction, 1 ligand (ANP), 20 pockets (best druggability 0.69). MolNFT v1 #139246 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5X9W
- Type
- protein
- Length
- 1,542 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA mismatch repair protein muts
- UniProt
- Q5F5J4
- Ligands
- ANP
- Pockets
- 20 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | DNA mismatch repair protein muts | protein | 771 | 42% helix, 19% strand | Q5F5J4 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 632 | 0.69 | 0.77 | 70 | empty |
| 2 | 92 | 0.69 | 0.93 | 25 | empty |
| 3 | 131 | 0.67 | 0.89 | 33 | empty |
| 4 | 261 | 0.67 | 0.83 | 46 | ANP |
| 5 | 415 | 0.65 | 0.79 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 1961 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5F5J4
- Elsewhere: RCSB PDB 5X9W · PDBe 5X9W · UniProt Q5F5J4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.