MolNFT v1 · #138856 · protein
Crystal structure of human NSUN6
5WWQ · Putative methyltransferase NSUN6: “Crystal structure of human NSUN6”. X-ray diffraction, 9 pockets (best druggability 0.73). MolNFT v1 #138856 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WWQ
- Type
- protein
- Length
- 887 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative methyltransferase NSUN6
- EC
- 2.1.1.-
- UniProt
- Q8TEA1
- Pockets
- 9 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative methyltransferase NSUN6 (EC 2.1.1.-) | protein | 441 | 32% helix, 24% strand | Q8TEA1 |
| B | Putative methyltransferase NSUN6 (EC 2.1.1.-) | protein | 446 | 31% helix, 24% strand | Q8TEA1 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1098 | 0.73 | 0.77 | 80 | empty |
| 2 | 630 | 0.70 | 0.78 | 70 | empty |
| 3 | 562 | 0.68 | 0.78 | 65 | empty |
| 4 | 237 | 0.60 | 0.80 | 27 | empty |
| 5 | 200 | 0.57 | 0.80 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 814 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TEA1
- Elsewhere: RCSB PDB 5WWQ · PDBe 5WWQ · UniProt Q8TEA1
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