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Crystal structure of human NSUN6

Analyse Crystal structure of human NSUN6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5WWQ
Type: protein
Length: 887 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative methyltransferase NSUN6
EC: 2.1.1.-
UniProt: Q8TEA1
Pockets: 9 · best druggability 0.73

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative methyltransferase NSUN6 (EC 2.1.1.-)	protein	441	32% helix, 24% strand	Q8TEA1
B	Putative methyltransferase NSUN6 (EC 2.1.1.-)	protein	446	31% helix, 24% strand	Q8TEA1

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1098	0.73	0.77	80	empty
2	630	0.70	0.78	70	empty
3	562	0.68	0.78	65	empty
4	237	0.60	0.80	27	empty
5	200	0.57	0.80	27	empty

Interfaces

1 interface between chains.

A–B · 814 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5WWQ · Crystal structure of human NSun6 · the same entry in another collection · chain A against A, TM-score 1.00
Q8TEA1 · AlphaFold monomer V2.0 prediction for tRNA (CYTOSINE(72)-C(5))-methyltransferase NSUN6… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TEA1
Elsewhere: RCSB PDB 5WWQ · PDBe 5WWQ · UniProt Q8TEA1

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