MolNFT v1 · #138730 · protein

Crystal of pyruvate kinase (pyk) from mycobacterium tuberculosis in complex with oxalate, soaked with allosteric activators AMP and glucose 6-phosphate

5WSC: “Crystal of pyruvate kinase (pyk) from mycobacterium tuberculosis in complex with oxalate, soaked with…”. X-ray diffraction, 6 ligands (AMP, OXL, G6P). MolNFT v1 #138730 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5WSC
Type: protein
Length: 1,884 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P9WKE5
Ligands: AMP, OXL, G6P, MG, K, PO4

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	—	protein	471	—	P9WKE5

Ligands and binding sites

AMP · Adenosine monophosphate · ligand · 4 copies · chains A, B, C, D
OXL · Oxalate ion · ligand · 4 copies · chains A, B, C, D
G6P · 6-O-phosphono-alpha-D-glucopyranose · sugar · 4 copies · chains A, B, C, D
MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
K · Potassium ion · metal · chains B
PO4 · Phosphate ion · ion · 2 copies · chains C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5WSC · Crystal of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate… · the same entry in another collection · chain B against B, TM-score 1.00
P9WKE5 · AlphaFold monomer V2.0 prediction for pyruvate kinase (P9WKE5) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P9WKE5
Elsewhere: RCSB PDB 5WSC · PDBe 5WSC · UniProt P9WKE5

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