MolNFT v1 · #138613 · protein

Corkscrew assembly of SOD1 residues 28-38 with familial mutation G37R

5WOR · Superoxide dismutase [cu-zn]: “Corkscrew assembly of SOD1 residues 28-38 with familial mutation G37R”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #138613 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5WOR
Type: protein
Length: 110 residues
Chains: 10
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Superoxide dismutase [cu-zn]
EC: 1.15.1.1
UniProt: P00441
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 64% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H, I, J	Superoxide dismutase [cu-zn] (EC 1.15.1.1)	protein	11	0% helix, 64% strand	P00441

Ligands and binding sites

MLI · Malonate ion · additive · 3 copies · chains A, B, E, F
GOL · Glycerol · additive · chains I, J

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	61	0.45	0.82	16	empty

Interfaces

31 interfaces between chains.

G–H · 496 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 475 Å² buried · 11 hydrogen bonds · protein-protein
C–D · 444 Å² buried · 12 hydrogen bonds · protein-protein
E–F · 416 Å² buried · 11 hydrogen bonds · protein-protein
B–C · 404 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

5WOR · Corkscrew assembly of SOD1 residues 28-38 with familial mutation G37R · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00441
Elsewhere: RCSB PDB 5WOR · PDBe 5WOR · UniProt P00441

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