MolNFT v1 · #138598 · protein
Crystal structure of transient receptor potential (TRP) channel TRPV6*
5WO7 · Transient receptor potential cation channel subfamily V…: “Crystal structure of transient receptor potential (TRP) channel TRPV6*”. X-ray diffraction, 2 ligands (DTB, CA), 7 pockets (best druggability 0.69). MolNFT v1 #138598 on…
- PDB
- 5WO7
- Type
- protein
- Length
- 595 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transient receptor potential cation channel subfamily V member 6
- UniProt
- Q9R186
- Ligands
- DTB, CA
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transient receptor potential cation channel subfamily V member 6 | protein | 595 | 55% helix, 4% strand | Q9R186 |
Ligands and binding sites
- DTB · 6-(5-methyl-2-oxo-imidazolidin-4-yl)-hexanoic acid · ligand · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 559 | 0.69 | 0.78 | 47 | empty |
| 2 | 222 | 0.65 | 0.83 | 33 | empty |
| 3 | 175 | 0.53 | 0.79 | 25 | DTB |
| 4 | 97 | 0.44 | 0.79 | 16 | empty |
| 5 | 106 | 0.44 | 0.78 | 23 | empty |
Compared structures
- 5WO7 · Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* · the same entry in another collection · chain A against A, TM-score 1.00
- Q9R186 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9R186
- Elsewhere: RCSB PDB 5WO7 · PDBe 5WO7 · UniProt Q9R186
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.