MolNFT v1 · #137959 · protein
Importin binding to nls peptide of DNA polymerase lambda
5W4G · Importin subunit alpha-1: “Importin binding to nls peptide of DNA polymerase lambda”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.42). MolNFT v1 #137959 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5W4G
- Type
- protein
- Length
- 438 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; DNA polymerase lambda
- EC
- 2.7.7.7, 4.2.99.-
- UniProt
- P52293, Q9UGP5
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Importin subunit alpha-1 | protein | 425 | 74% helix, 0% strand | P52293 |
| A | DNA polymerase lambda (EC 2.7.7.7, 4.2.99.-) | protein | 13 | 0% helix, 0% strand | Q9UGP5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.42 | 0.81 | 13 | empty |
| 2 | 53 | 0.29 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- B–A · 935 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt Q9UGP5
- Elsewhere: RCSB PDB 5W4G · PDBe 5W4G · UniProt P52293 · UniProt Q9UGP5
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