MolNFT v1 · #13776 · protein

A structural analysis of metal substitutions in thermolysin

1LNE: “A structural analysis of metal substitutions in thermolysin”. X-ray diffraction, 2 ligands (CD, CA), 1 pocket (best druggability 0.26). MolNFT v1 #13776 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1LNE
Type: protein
Length: 318 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Thermolysin
EC: 3.4.24.27
UniProt: P00800
Ligands: CD, CA
Pockets: 1 · best druggability 0.26

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Thermolysin (EC 3.4.24.27)	protein	318	41% helix, 17% strand	P00800

Ligands and binding sites

CD · Cadmium ion · metal · 4 copies · chains E
CA · Calcium ion · metal · 2 copies · chains E
DMS · Dimethyl sulfoxide · additive · chains E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.26	0.74	15	empty

Compared structures

1LNE · A structural analysis of metal substitutions in thermolysin · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00800
Elsewhere: RCSB PDB 1LNE · PDBe 1LNE · UniProt P00800

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