MolNFT v1 · #137345 · protein
The structure of human camkii with bound inhibitor
5VLO: “The structure of human camkii with bound inhibitor”. X-ray diffraction, 1 ligand (9EJ). MolNFT v1 #137345 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5VLO
- Type
- protein
- Length
- 583 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q13557
- Ligands
- 9EJ
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 290 | — | Q13557 |
| B | — | protein | 293 | — | Q13557 |
Ligands and binding sites
- 9EJ · N-[(2S)-2-(diethylamino)propyl]-2-[(2S)-2-(methylcarbamoyl)azetidin-1-yl]-6-[5-(thiophen-2-yl) pyrazolo[1,5-a]pyrimidin-3-yl]pyridine-4-carboxamide · ligand · 2 copies · chains A, B
- DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5VLO · The structure of human CamKII with bound inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- Q13557 · AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type II… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13557
- Elsewhere: RCSB PDB 5VLO · PDBe 5VLO · UniProt Q13557
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