UniProt Q13557
Calcium/calmodulin-dependent protein kinase type II subunit delta (Q13557)
Calcium/calmodulin-dependent protein kinase type II subunit delta (UniProt Q13557), EC 2.7.11.17: 12 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 10 pockets. Binding sites, druggability and…
- UniProt
- Q13557
- Protein
- Calcium/calmodulin-dependent protein kinase type II subunit delta
- EC
- 2.7.11.17
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 10 · 2 records with a druggable one
Structures
13 records of Q13557 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VN9 | Crystal Structure of Human Calcium Calmodulin dependent Protein Kinase II delta isoform 1, CAMKD | x-ray diffraction | A, B | — | — |
| 2VN9 | Crystal structure of human calcium calmodulin dependent protein kinase II delta isoform 1, camkd | x-ray diffraction | A, B | — | — |
| 2W2C | Structure of the tetradecameric oligomerisation domain of calcium- calmodulin dependent protein… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N | — | — |
| 2W2C | Structure of the tetradecameric oligomerisation domain of calcium- calmodulin dependent protein… | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N | — | — |
| 2WEL | Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex… | x-ray diffraction | A | — | — |
| 2WEL | Crystal structure of SU6656-bound CALCIUM/CALMODULIN-dependent protein kinase II delta in complex… | x-ray diffraction | A | — | — |
| 3GP2 | Calmodulin bound to peptide from calmodulin kinase II (CaMKII) | x-ray diffraction | B | — | — |
| 3GP2 | Calmodulin bound to peptide from calmodulin kinase II (camkii) | x-ray diffraction | B | — | — |
| 5VLO | The structure of human camkii with bound inhibitor | x-ray diffraction | A, B | 9EJ | — |
| 6AYW | The structure of human CamKII with bound inhibitor | x-ray diffraction | A, B | C2V | 5 (best 0.73) |
| 6AYW | The structure of human camkii with bound inhibitor | x-ray diffraction | A, B | C2V | — |
| 7ZRP | 2.65 Angstrom crystal structure of Ca/CaM:CaMKIIdelta peptide complex | x-ray diffraction | B, D | ZN | 5 (best 0.55) |
| Q13557 | AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type II subunit… | predicted | A | — | — |
Ligands
- C2V · N-[2-(dimethylamino)ethyl]-3-[6-(thiophen-2-yl) imidazo[1,2-b]pyridazin-3-yl]benzamide · in 2 records
- 9EJ · N-[(2S)-2-(diethylamino)propyl]-2-[(2S)-2-(methylcarbamoyl)azetidin-1-yl]-6-[5-(thiophen-2-yl) pyrazolo[1,5-a]pyrimidin-3-yl]pyridine-4-carboxamide · in 1 record
- ZN · Zinc ion · in 1 record
Experiment against prediction
- 6AYW chain B against the predicted model Q13557: TM-score 0.98, RMSD 0.91 Å
- 6AYW chain B against the predicted model Q13557: TM-score 0.98, RMSD 0.91 Å
- 5VLO chain B against the predicted model Q13557: TM-score 0.98, RMSD 0.96 Å
- 2VN9 chain A against the predicted model Q13557: TM-score 0.98, RMSD 1.55 Å
- 2VN9 chain A against the predicted model Q13557: TM-score 0.98, RMSD 1.55 Å
- 6AYW chain A against the predicted model Q13557: TM-score 0.97, RMSD 1.26 Å
- 6AYW chain A against the predicted model Q13557: TM-score 0.97, RMSD 1.26 Å
- 5VLO chain A against the predicted model Q13557: TM-score 0.97, RMSD 1.27 Å
- 2W2C chain M against the predicted model Q13557: TM-score 0.96, RMSD 0.86 Å
- 2W2C chain M against the predicted model Q13557: TM-score 0.96, RMSD 0.86 Å
Elsewhere
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