MolNFT v1 · #136972 · protein
Crystal structure of small molecule ars-1620 covalently bound to K-RAS G12C
5V9U: “Crystal structure of small molecule ars-1620 covalently bound to K-RAS G12C”. X-ray diffraction, 3 ligands (91S, GDP, CA). MolNFT v1 #136972 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5V9U
- Type
- protein
- Length
- 336 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P01116
- Ligands
- 91S, GDP, CA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 169 | — | P01116 |
| B | — | protein | 167 | — | P01116 |
Ligands and binding sites
- 91S · (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one · ligand · 2 copies · chains A, B
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
- CA · Calcium ion · metal · 6 copies · chains A, B
- GOL · Glycerol · additive · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01116
- Elsewhere: RCSB PDB 5V9U · PDBe 5V9U · UniProt P01116
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