MolNFT v1 · #136923 · protein
Crystal structure of myosin 1B residues 1-728 with bound sulfate and calmodulin
5V7X · Unconventional myosin-ib: “Crystal structure of myosin 1B residues 1-728 with bound sulfate and calmodulin”. X-ray diffraction, 1 ligand (SO4), 12 pockets (best druggability 0.74). MolNFT v1 #136923 on GenesisL1: 3D structure…
- PDB
- 5V7X
- Type
- protein
- Length
- 866 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Unconventional myosin-ib; Calmodulin-1
- UniProt
- Q05096, P0DP23
- Ligands
- SO4
- Pockets
- 12 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Unconventional myosin-ib | protein | 721 | 47% helix, 13% strand | Q05096 |
| B | Calmodulin-1 | protein | 145 | 55% helix, 4% strand | P0DP23 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 887 | 0.74 | 0.78 | 83 | empty |
| 2 | 282 | 0.69 | 0.84 | 43 | SO4 |
| 3 | 125 | 0.57 | 0.84 | 26 | empty |
| 4 | 111 | 0.54 | 0.83 | 17 | empty |
| 5 | 143 | 0.47 | 0.78 | 28 | empty |
Interfaces
1 interface between chains.
- A–B · 1775 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5V7X · Crystal Structure of Myosin 1b residues 1-728 with bound sulfate and Calmodulin · the same entry in another collection · chain A against A, TM-score 1.00
- Q05096 · AlphaFold monomer V2.0 prediction for unconventional myosin-ib (Q05096) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain B against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05096
- Every structure of UniProt P0DP23
- Elsewhere: RCSB PDB 5V7X · PDBe 5V7X · UniProt Q05096 · UniProt P0DP23
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