MolNFT v1 · #136889 · protein
Crystal structure of small molecule aziridine 3 covalently bound to K- RAS G12C
5V6V: “Crystal structure of small molecule aziridine 3 covalently bound to K- RAS G12C”. X-ray diffraction, 3 ligands (GDP, 8YA, CA). MolNFT v1 #136889 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5V6V
- Type
- protein
- Length
- 333 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P01116
- Ligands
- GDP, 8YA, CA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 166 | — | P01116 |
| B | — | protein | 167 | — | P01116 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
- 8YA · 3-amino-1-{4-[6-chloro-8-fluoro-7-(5-methyl-1H-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl}propan-1-one · ligand · 2 copies · chains A, B
- CA · Calcium ion · metal · 6 copies · chains A, B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5V6V · Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01116
- Elsewhere: RCSB PDB 5V6V · PDBe 5V6V · UniProt P01116
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