MolNFT v1 · #136770 · protein
Crystal structure of tgt in complex with 4-(AMINOMETHANE)CYCLOHEXANE- 1-carboxylic acid
5V3C · Queuine tRNA-ribosyltransferase: “Crystal structure of tgt in complex with 4-(AMINOMETHANE)CYCLOHEXANE- 1-carboxylic acid”. X-ray diffraction, 2 ligands (AMH, ZN), 1 pocket (best druggability 0.60). MolNFT v1 #136770 on GenesisL1…
- PDB
- 5V3C
- Type
- protein
- Length
- 373 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Queuine tRNA-ribosyltransferase
- EC
- 2.4.2.29
- UniProt
- P28720
- Ligands
- AMH, ZN
- Pockets
- 1 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Queuine tRNA-ribosyltransferase (EC 2.4.2.29) | protein | 373 | 46% helix, 17% strand | P28720 |
Ligands and binding sites
- AMH · Trans-4-aminomethylcyclohexane-1-carboxylic acid · ligand · chains A
- ZN · Zinc ion · metal · chains A
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
- DMS · Dimethyl sulfoxide · additive · 2 copies · chains A
- PGE · Triethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 194 | 0.60 | 0.82 | 30 | AMH |
Compared structures
- 5V3C · Crystal structure of TGT in complex with 4-(aminomethane)cyclohexane-1-carboxylic acid · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28720
- Elsewhere: RCSB PDB 5V3C · PDBe 5V3C · UniProt P28720
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