MolNFT v1 · #136748 · protein
Cav BETA2A subunit: CAV1.2 aid-cen complex
5V2Q · Voltage-dependent L-type calcium channel subunit beta-2…: “Cav BETA2A subunit: CAV1.2 aid-cen complex”. X-ray diffraction, 2 ligands (8VY, CL), 1 pocket (best druggability 0.46). MolNFT v1 #136748 on GenesisL1: 3D structure, binding…
- PDB
- 5V2Q
- Type
- protein
- Length
- 317 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-dependent L-type calcium channel subunit beta-2, voltage-dependent L-type calcium…
- UniProt
- Q8VGC3, Q13936
- Ligands
- 8VY, CL
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Voltage-dependent L-type calcium channel subunit beta-2, voltage-dependent L-type calcium channel subunit beta-2 | protein | 298 | 43% helix, 18% strand | Q8VGC3 |
| B | Voltage-dependent L-type calcium channel subunit alpha-1C | protein | 19 | 79% helix, 0% strand | Q13936 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 179 | 0.46 | 0.75 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 818 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 5V2Q · CaV beta2a subunit: CaV1.2 AID-CEN complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q8VGC3 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q13936 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain B against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VGC3
- Every structure of UniProt Q13936
- Elsewhere: RCSB PDB 5V2Q · PDBe 5V2Q · UniProt Q8VGC3 · UniProt Q13936
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