MolNFT v1 · #136544 · protein
Crystal structure of EGFR kinase domain (L858R, T790M, V948R) in complex with the covalent inhibitor co-1686
5UWD: “Crystal structure of EGFR kinase domain (L858R, T790M, V948R) in complex with the covalent inhibitor co-1686”. X-ray diffraction, 1 ligand (8OV). MolNFT v1 #136544 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5UWD
- Type
- protein
- Length
- 271 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P00533
- Ligands
- 8OV
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 271 | — | P00533 |
Ligands and binding sites
- 8OV · N-(3-{[2-{[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)propanamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5UWD · Crystal structure of EGFR kinase domain (L858R, T790M, V948R) in complex with the… · the same entry in another collection · chain A against A, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Elsewhere: RCSB PDB 5UWD · PDBe 5UWD · UniProt P00533
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